Prime of Life Brain Diseases

Neurodegenerative diseases are not limited to the elderly. Known as "prime of life" brain diseases, these frontotemporal disorders start developing in middle age or earlier, during the "prime years" of one's life. Roughly 60% of people with frontotemporal disorders are 45 to 64 years of age (NIH).

Understanding Tauopathies

Tauopathies encompass over 20 clinicopathological entities, including Alzheimer's disease, Progressive Supranuclear Palsy (PSP), and Corticobasal degeneration (CBD). They all involve the aggregation of tau protein into neurofibrillary tangles (NFTs) in the brain. 

NFT

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(A)

(B)

Normal microtubule (A) and one affected with tauopathy (B)

Progressive Supranuclear Palsy (PSP)

Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease that has no known cause or cure. The disease involves the gradual deterioration and death of certain parts of the brain, leading to loss of balance, difficulty moving the eyes, and dementia. PSP affects 5-6 people in every 100,000. However, cases may go undiagnosed or misdiagnosed, which makes the true frequency much more difficult to determine.

Corticobasal Degeneration (CBD)

Corticobasal degeneration (CBD) is a rare neurodegenerative disease that has no known cause or cure. It primarily impacts the cerebral cortex and basal ganglia of the brain. CBD is characterized by disorders in movement and cognition. CBD affects 5-6 people in every 100,000. However, cases may go undiagnosed or misdiagnosed, which makes the true frequency much more difficult to determine.

Multiple System Atrophy (MSA)

Multiple System Atrophy (MSA) is a rare neurodegenerative disease that is caused by the progressive degeneration of neuron in several parts of the brain, such as the basal ganglia, inferior olivary nucleus, and cerebellum. MSA is characterized by autonomic nervous system dysfunction, tremors, slow movement, and ataxia. 

Frequently Asked Questions

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